Myosin V-IN-1
Product Specifications
UNSPSC Description
Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2].
Target Antigen
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/myosin-v-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(SCC2=CC(NC3=NC(NN=C4C5=CC=C(N6CCOCC6)C=C5)=C4C=N3)=CC=C2)=CC=C1)O
Molecular Weight
538.62
References & Citations
[1]Maschi D, et al. Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses. Front Synaptic Neurosci. 2021 Apr 15;13:650334. |[2]Islam K, et al. A myosin V inhibitor based on privileged chemical scaffolds. Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152949/Myosin-V-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152949/Myosin-V-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1259177-59-7
Available Sizes
Curated Selection
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