Bim BH3, Peptide IV

Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins[1][2].

Product Specifications

CAS Number

[721885-31-0]

UNSPSC

12352209

Target

Bcl-2 Family

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bim-bh3-peptide-iv.html

Purity

99.35

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@H](CCSC)NC([C@@H](N)CC(O)=O)=O)=O)=O)N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)CC2=CC=C(C=C2)O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O

Molecular Formula

C145H222N44O41S

Molecular Weight

3269.65

References & Citations

[1]Zhu Y, et al. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondriain T cells. Proc Natl Acad Sci U S A. 2004 May 18;101 (20) :7681-6.|[2]Lee EF, et al. High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl. 2009;48 (24) :4318-22.