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Lefty-A/TGF-beta 4, Human (HEK293, His)

Lefty-A/TGF-beta 4 Protein, Human is a secreted protein belonging to the transforming growth factor-beta (TGF-β) family, which plays an important role in the development of human left-right axis. Lefty-A/TGF-beta 4 Protein, Human (HEK293, His) is a recombinant Lefty-A/TGF-β 4 protein expressed by HEK293 with an N-6*His tag[1][2][3][4][5].

Product Specifications

Product Name Alternative

Lefty-A/TGF-beta 4 Protein, Human (HEK293, His), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/lefty-a-tgf-beta-4-protein-human-hek-293-his.html

Purity

96.00

Smiles

LTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKHHHHHH&FSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP

Molecular Formula

7044 (Gene_ID) O00292 (L22-K76) &O00292 (F78-P366) (Accession)

Molecular Weight

Approximately 45-50 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Kosaki K, et al. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. Am J Hum Genet. 1999 Mar;64 (3) :712-21.|[2]Yang YR, et al. LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway. Mol Immunol. 2020 Oct;126:31-39.|[3]Besser D. Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3. J Biol Chem. 2004 Oct 22;279 (43) :45076-84. |[4]Zheng RP, et al. Lefty A protein inhibits TGF-β1-mediated apoptosis in human renal tubular epithelial cells. Mol Med Rep. 2013 Aug;8 (2) :621-5.|[5]Li Y, et al. Lefty A attenuates the TGF-beta1-induced epithelial to mesenchymal transition of human renal proximal epithelial tubular cells. Mol Cell Biochem. 2010 Jun;339 (1-2) :263-70.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

Frequently Asked Questions

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