4-Methoxylonchocarpin

4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS) -induced colitis mouse model[1].

Product Specifications

CAS Number

[51589-67-4]

UNSPSC

12352005

Target

Interleukin Related; NF-κB; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-methoxylonchocarpin.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

OC1=C2C(OC(C)(C=C2)C)=CC=C1C(/C=C/C3=CC=C(C=C3)OC)=O

Molecular Formula

C21H20O4

Molecular Weight

336.38

References & Citations

[1]Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97.