Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Rapamycin (GMP)

Rapamycin (Sirolimus) (GMP) is Rapamycin produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

Product Specifications

CAS Number

53123-88-9

Product Name Alternative

Sirolimus (GMP) ; AY-22989 (GMP) ; NSC 226080 (GMP)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Autophagy; Bacterial; Endogenous Metabolite; FKBP; Fungal; mTOR

Type

GMP Small Molecules

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/rapamycin-gmp.html

Purity

99.8

Solubility

10 mM in DMSO

Smiles

O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O

Molecular Formula

C51H79NO13

Molecular Weight

914.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282 (18), 13395-13401. |[2]Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30 (34) :11388-97. |[3]Niu H, et al. Rapamycin potentiates cytotoxicity by RP-56976 possibly through downregulation of Survivin in lung cancer cells. J Exp Clin Cancer Res. 2011 Mar 10;30:28.|[4]Zhang JW, et al. Metformin synergizes with rapamycin to inhibit the growth of pancreatic cancer in vitro and in vivo. Oncol Lett. 2018 Feb;15 (2) :1811-1816.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from moisture

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

1-Anilino-3-phenylimino-1-propene Hydrochloride
TRC-A458920-5G 5 g

1-Anilino-3-phenylimino-1-propene Hydrochloride

Sign In for Pricing
View Details
MBNL1 (NM_207297) Human Over-expression Lysate
LY404080 100 µg

MBNL1 (NM_207297) Human Over-expression Lysate

Sign In for Pricing
View Details
6-Aminoquinoline-D6
TRC-A629162-250MG 250 mg

6-Aminoquinoline-D6

Sign In for Pricing
View Details
(3R)-3-Mercapto-1-hexanol
TRC-M574520-100MG 100 mg

(3R)-3-Mercapto-1-hexanol

Sign In for Pricing
View Details
L-Anserine Nitrate Salt
TRC-A678250-1G 1 g

L-Anserine Nitrate Salt

Sign In for Pricing
View Details
CD1E (NM_001042583) Human Over-expression Lysate
LC420991 20 µg

CD1E (NM_001042583) Human Over-expression Lysate

Sign In for Pricing
View Details