DMH4
DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM[1].
Product Specifications
CAS Number
[515880-75-8]
UNSPSC
12352005
Hazard Statement
H302
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmh4.html
Purity
98.98
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=C(C3=CC=CC=C3)C=NN1C=C(C4=CC=C(OCCN5CCOCC5)C=C4)C=N2
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Precautions
H302
References & Citations
[1]Hao J, et al. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010 Feb 19;5 (2) :245-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Available Sizes
Curated Selection
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