DMH4

DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM[1].

Product Specifications

CAS Number

[515880-75-8]

UNSPSC

12352005

Hazard Statement

H302

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dmh4.html

Purity

98.98

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=C(C3=CC=CC=C3)C=NN1C=C(C4=CC=C(OCCN5CCOCC5)C=C4)C=N2

Molecular Formula

C24H24N4O2

Molecular Weight

400.47

Precautions

H302

References & Citations

[1]Hao J, et al. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010 Feb 19;5 (2) :245-53.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

Available Sizes

Curated Selection

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