Penciclovir

Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 μg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse[1][2].

Product Specifications

CAS Number

[39809-25-1]

Product Name Alternative

BRL 39123; VSA 671

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Penciclovir.html

Purity

99.92

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC(N)=NC2=C1N=CN2CCC(CO)CO

Molecular Formula

C10H15N5O3

Molecular Weight

253.26

Precautions

H302, H315, H319, H335

References & Citations

[1]M.R. Boyd, et al. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chemistry and Chemotherapy, 1993, (1) : 3-11.|[2]de la Fuente R, et al. The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model. Antiviral Res. 1992 May;18 (1) :77-89.