NNC 05-2090 (hydrochloride)

NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50: 10.6 μM) . NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases[1][2][3].

Product Specifications

CAS Number

[184845-18-9]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nnc-05-2090-hydrochloride.html

Purity

99.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1(CCN(CC1)CCCN2C3=C(C4=C2C=CC=C4)C=CC=C3)C5=C(OC)C=CC=C5.Cl

Molecular Formula

C27H31ClN2O2

Molecular Weight

451.00

References & Citations

[1]Dalby NO, et al. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 1997 Jul;28 (1) :51-61.|[2]N O Dalby, et al. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 1997 Jul;28 (1) :51-61.|[3]Jinzenji A, et al. Antiallodynic action of 1- (3- (9H-Carbazol-9-yl) -1-propyl) -4- (2-methyoxyphenyl) -4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci. 2014;125 (2) :217-26.