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Gliquidone (Standard)

Gliquidone (Standard) is the analytical standard of Gliquidone. This product is intended for research and analytical applications. Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS -induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers[1][2].

Product Specifications

CAS Number

33342-05-1

Product Name Alternative

AR-DF 26 (Standard)

UNSPSC

12352005

Target

COX; ERK; Interleukin Related; NF-κB; Potassium Channel; Reference Standards; STAT

Type

Reference Standards

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Others; Stem Cell/Wnt

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gliquidone-standard.html

Smiles

O=S(C1=CC=C(CCN(C(C(C)(C)C2=C3C=C(OC)C=C2)=O)C3=O)C=C1)(NC(NC4CCCCC4)=O)=O

Molecular Formula

C27H33N3O6S

Molecular Weight

527.63

References & Citations

[1]Kim, J., et al., (2021) . The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome. Frontiers in aging neuroscience, 13, 754123. |[2]M. Shamona, et al., Vibrational spectra of second generation antidiabetic drug gliquidone exhibiting anticancer activity, antioxidant activity using both the experimental and theoretical approach, Journal of Molecular Liquids, Volume 411, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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