Bay 60-7550
Bay 60-7550 is a potent and selective PDE2 inhibitor with a Ki of 3.8 nM.
Product Specifications
CAS Number
[439083-90-6]
Product Name Alternative
BAY 607550
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Bay-60-7550.html
Purity
98.39
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1N=C(NN2C1=C(N=C2[C@@H](CCCC3=CC=CC=C3)[C@@H](C)O)C)CC4=CC=C(C(OC)=C4)OC
Molecular Formula
C27H32N4O4
Molecular Weight
476.57
References & Citations
[1]Masood A, et al. Anxiolytic effects of phosphodiesterase-2 inhibitors associated with increased cGMP signaling. J Pharmacol Exp Ther. 2009 Nov;331 (2) :690-9.|[2]Bubb KJ, et al. Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension. Circulation. 2014 Aug 5;130 (6) :496-507.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE2
Available Sizes
Curated Selection
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