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7- (2-Aminoethyl) camptothecin (TFA)

7- (2-Aminoethyl) camptothecin TFA (7CPT TFA) is the TFA salt form of Camptothecin derivative 7- (2-Aminoethyl) camptothecin (HY-159162). 7- (2-Aminoethyl) camptothecin TFA can be used for synthesis of conjugate with triple helix-forming oligonucleotides (TFOs) and camptothecin (CPT). The TFO-CPT conjugate is used for DNA cleavage[1].

Product Specifications

Product Name Alternative

7CPT (TFA)

UNSPSC

12352005

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/7-2-aminoethyl-camptothecin-tfa.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N2C(C3=NC4=CC=CC=C4C(CCN)=C3C2)=CC5=C1COC([C@]5(O)CC)=O.OC(C(F)(F)F)=O

Molecular Formula

C24H22F3N3O6

Molecular Weight

505.44

References & Citations

[1]Arimondo P B, et al. Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I[J]. Journal of Biological Chemistry, 2002, 277 (5) : 3132-3140.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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