7- (2-Aminoethyl) camptothecin (TFA)
7- (2-Aminoethyl) camptothecin TFA (7CPT TFA) is the TFA salt form of Camptothecin derivative 7- (2-Aminoethyl) camptothecin (HY-159162). 7- (2-Aminoethyl) camptothecin TFA can be used for synthesis of conjugate with triple helix-forming oligonucleotides (TFOs) and camptothecin (CPT). The TFO-CPT conjugate is used for DNA cleavage[1].
Product Specifications
Product Name Alternative
7CPT (TFA)
UNSPSC
12352005
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/7-2-aminoethyl-camptothecin-tfa.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N2C(C3=NC4=CC=CC=C4C(CCN)=C3C2)=CC5=C1COC([C@]5(O)CC)=O.OC(C(F)(F)F)=O
Molecular Formula
C24H22F3N3O6
Molecular Weight
505.44
References & Citations
[1]Arimondo P B, et al. Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I[J]. Journal of Biological Chemistry, 2002, 277 (5) : 3132-3140.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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