IHCK-37
IHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1].
Product Specifications
CAS Number
516478-09-4
Product Name Alternative
ASN05260065
UNSPSC
12352005
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ihck-37.html
Purity
99.52
Solubility
DMSO : 275 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC=C1N2CCOCC2)CSC3=C(C4=C(CCCC4)S5)C5=NC(CCC6=CC=CC=C6)=N3
Molecular Formula
C30H32N4O2S2
Molecular Weight
544.73
References & Citations
[1]Cristina Tintori, et al. Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. ChemMedChem. 2013 Aug;8 (8) :1353-60.|[2]Fernanda Marconi Roversi, et al. Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863 (2) :450-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNUB1561-500 1x 500 µL
Filaggrin (Keratinocyte Differentiation Marker) (FLG/1561), 0.2mg/mL
Sign In for Pricing
View Details 
BNC880877-500 1x 500 µL
CD99 (MIC2/877), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
