MDL 72527

MDL 72527 is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects[1][2].

Product Specifications

CAS Number

[93565-01-6]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mdl-72527.html

Purity

98.0

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C=C=CCNCCCCNCC=C=C.[H]Cl.[H]Cl

Molecular Formula

C12H22Cl2N2

Molecular Weight

265.22

Precautions

H315, H319, H335

References & Citations

[1]Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72 (2) :765-70.|[2]Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14) : sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763 (10) :1040-50.