Recombinant Human Claudin-9 (CLDN9), partial-Detergent (Active)
Product Specifications
Product Name Alternative
Claudin-9; CLDN9
Abbreviation
Recombinant Human CLDN9 protein, partial-Detergent (Active)
Gene Name
CLDN9
UniProt
O95484
Expression Region
2-217aa
Organism
Homo sapiens (Human)
Target Sequence
ASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV
Tag
N-terminal 10xHis-tagged and C-terminal Twin-Strep-tagged
Type
MP-Detergent Transmembrane Protein & Active Protein & In Stock Protein
Source
Mammalian cell
Field of Research
Cancer
Relevance
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Endotoxin
Less than 1.0 EU/μg as determined by LAL method.
Purity
Greater than 95% as determined by SDS-PAGE.
Activity
Yes
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU) . The EC50 is 2.812-3.524 ng/mL.
Form
Liquid
Buffer
50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Reconstitution
/
Molecular Weight
27.3 kDa
References & Citations
Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus. Zheng A., Yuan F., Li Y., Zhu F., Hou P., Li J., Song X., Ding M., Deng H. J. Virol. 81:12465-12471 (2007)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Partial
Available Sizes
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