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Succinic acid (sodium)

Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten eleven translocation 1) . Succinic acid sodium can be used for gestational hypertension research[1][2][3].

Product Specifications

CAS Number

14047-56-4

Product Name Alternative

Wormwood acid (sodium)

UNSPSC

12352211

Target

Potassium Channel; TET Protein

Type

Reference compound

Related Pathways

Epigenetics; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/succinic-acid-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(CCC(O)=O)O.[Na].[x]

Molecular Formula

C4H6O4.xNa

References & Citations

[1]Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73 (25) :3257-64. |[2]Inagaki A, et al. Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. J Nutr Sci Vitaminol (Tokyo) . 2007 Aug;53 (4) :377-9. |[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22 (4) :1072.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

TET1

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