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AF38469

AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.

Product Specifications

CAS Number

1531634-31-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AF38469.html

Purity

99.28

Solubility

DMSO : ≥ 43 mg/mL

Smiles

O=C(NC1=CC=CC(C)=N1)C2=CC=C(C(F)(F)F)C=C2C(O)=O

Molecular Formula

C15H11F3N2O3

Molecular Weight

324.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24 (1) :177-80.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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