AF38469
AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
Product Specifications
CAS Number
1531634-31-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AF38469.html
Purity
99.28
Solubility
DMSO : ≥ 43 mg/mL
Smiles
O=C(NC1=CC=CC(C)=N1)C2=CC=C(C(F)(F)F)C=C2C(O)=O
Molecular Formula
C15H11F3N2O3
Molecular Weight
324.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24 (1) :177-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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