Boc-NH-PEG4-CH2CH2COOH
Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC) [2].
Product Specifications
CAS Number
[756525-91-4]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic_acid.html
Purity
99.85
Solubility
10 mM in DMSO
Smiles
CC(C)(OC(NCCOCCOCCOCCOCCC(O)=O)=O)C
Molecular Formula
C16H31NO8
Molecular Weight
365.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1.|[2]Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; PEG Linkers
Available Sizes
Curated Selection
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