Boc-NH-PEG4-CH2CH2COOH

Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC) [2].

Product Specifications

CAS Number

[756525-91-4]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic_acid.html

Purity

99.85

Solubility

10 mM in DMSO

Smiles

CC(C)(OC(NCCOCCOCCOCCOCCC(O)=O)=O)C

Molecular Formula

C16H31NO8

Molecular Weight

365.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1.|[2]Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.