Topoisomerase II inhibitor 13

Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1].

Product Specifications

CAS Number

[451515-89-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-ii-inhibitor-13.html

Purity

98.07

Solubility

DMSO : 12.5 mg/mL (ultrasonic) |DMSO : 12.5 mg/mL (ultrasonic; warming)

Smiles

N#CC1=NC2=C(N(CCCN(CC)CC)C(N)=C2C3=NC4=C(N3)C=CC=C4)N=C1C#N

Molecular Formula

C22H23N9

Molecular Weight

413.48

Precautions

H302, H315, H319

References & Citations

[1]Li P H, et al. Synthesis and mechanism studies of 1, 3-benzoazolyl substituted pyrrolo [2, 3-b] pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors. Journal of Medicinal Chemistry, 2016, 59 (1) : 238-252.