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L-Kynurenine

Product Specifications

UNSPSC Description

L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

Target Antigen

Aryl Hydrocarbon Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

Immunology/Inflammation;Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/L-Kynurenine.html

Purity

99.93

Solubility

DMSO : 11.67 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](N)CC(C1=CC=CC=C1N)=O

Molecular Weight

208.217

References & Citations

[1]Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.|[2]Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7.|[3]Nozaki K, et al. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab. 1992 May;12(3):400-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-104026/L-Kynurenine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-104026/L-Kynurenine-SDS-MedChemExpress.pdf

Clinical Information

Phase 1

CAS Number

2922-83-0

Available Sizes

Curated Selection

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