VH 101, acid
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand[1].
Product Specifications
CAS Number
[2408341-97-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vh-101-acid.html
Purity
98.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(O)=O)=O)=O
Molecular Formula
C28H35FN4O6S
Molecular Weight
574.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Jian Jin, et al. Protein tyrosine kinase 6 (ptk6) degradation / disruption compounds and methods of use. WO2020010204A1.2020-01-09.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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