RIG012
RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM using the NADH-coupled ATPase assay. RIG012 inhibits IFN-β and ISG hRsad2 expression[1].
Product Specifications
CAS Number
2642218-43-5
UNSPSC
12352005
Target
IFNAR
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/rig012.html
Concentration
10mM
Purity
99.0
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1N=C2C3=C(C(C(OCC4=CC=CC=C4)=C2C1(CC)CC)=O)C=CC=C3
Molecular Formula
C23H21NO3
Molecular Weight
359.42
References & Citations
[1]David C Rawling, et al. Small-Molecule Antagonists of the RIG-I Innate Immune Receptor. ACS Chem Biol. 2020 Feb 21;15 (2) :311-317.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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