TROY/TNFRSF19, Human (HEK293, His)

TROY Protein also known as TAJ, TNFRSF19, a type I transmembrane receptor, is a member of the TNF receptor superfamily. TROY Protein is involved in embryonic development and the development of skin and hair follicles[1]. TROY Protein inhibits cell proliferation in vitro and shows antitumor activity in xenografted models[2]. TROY/TNFRSF19 Protein, Human (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 170 amino acids (M1-L170) and is produced in HEK293 cells.

ESGDCRQQEF RDRSGNCVPC NQCGPGMELS KECGFGYGED AQCVTCRLHR FKEDWGFQKC KPCLDCAVVN RFQKANCSAT SDAICGDCLP GFYRKTKLVG FQDMECVPCG DPPPPYEPHC ASKVNLVKIA STASSPRDTA L

[1]Kojima T, et al. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J Biol Chem. 2000 Jul 7;275(27):20742-7.|[2]Liu X, et al. TROY interacts with RKIP to promote glioma development. Oncogene. 2019 Feb;38(9):1544-1559.|[3]Ding Z, et al. TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance. Neoplasia. 2020 Sep;22(9):352-364.|[4]Fafilek B, et al. Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. Gastroenterology. 2013 Feb;144(2):381-391.