MK-8617
MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
Product Specifications
CAS Number
1187990-87-9
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/MK-8617.html
Purity
99.92
Solubility
DMSO : 5.71 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Molecular Formula
C24H21N5O4
Molecular Weight
443.45
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Debenham JS, et al. Discovery of N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59 (24) :11039-11049.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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