Timcodar
Timcodar is a macrolide agent that can significantly inhibit fat accumulation during adipogenesis, with an effect similar to rapamycin. However, unlike rapamycin, Timcodar does not cause immunosuppression and glucose resistance. Timcodar can effectively inhibit adipogenesis transcriptional regulators PPAR and C/EBP, thereby inhibiting genes involved in fat accumulation.
Product Specifications
CAS Number
179033-51-3
Product Name Alternative
VX-853
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/timcodar.html
Smiles
O=C(N(CC1=CC=CC=C1)C(CCC2=CC=NC=C2)CCC3=CC=NC=C3)[C@H](CC4=CC=C(Cl)C=C4)N(C)C(C(C5=CC(OC)=C(OC)C(OC)=C5)=O)=O
Molecular Formula
C43H45ClN4O6
Molecular Weight
749.29
References & Citations
[1]Timcodar (VX‐853) Is a Non‐FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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