HJ-PI01

HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research[1].

Product Specifications

CAS Number

[6192-43-4]

Product Name Alternative

10-Acetylphenoxazine

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hj-pi01.html

Purity

99.50

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(N1C2=C(C=CC=C2)OC3=CC=CC=C13)=O

Molecular Formula

C14H11NO2

Molecular Weight

225.24

Precautions

H302, H315, H319

References & Citations

[1]Zhao YQ, et al. Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer. Acta Pharmacol Sin. 2016 Sep;37 (9) :1237-50.