HJ-PI01
HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research[1].
Product Specifications
CAS Number
[6192-43-4]
Product Name Alternative
10-Acetylphenoxazine
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hj-pi01.html
Purity
99.50
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(N1C2=C(C=CC=C2)OC3=CC=CC=C13)=O
Molecular Formula
C14H11NO2
Molecular Weight
225.24
Precautions
H302, H315, H319
References & Citations
[1]Zhao YQ, et al. Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer. Acta Pharmacol Sin. 2016 Sep;37 (9) :1237-50.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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