PC786

PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A (IC50 RSV-B (IC50, 1.3 to 50.6 nM) [1].

Product Specifications

CAS Number

[1902114-15-1]

UNSPSC

12352005

Target

RSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/PC786.html

Purity

99.11

Solubility

DMSO : 130 mg/mL (ultrasonic)

Smiles

O=C(C(S1)=CC2=C1C3=CC=CC=C3N(C(C4=CC=C(NC(C5=CC(C)=CN=C5N6CC7(CCOCC7)C6)=O)C=C4)=O)CC2)NC8=C(C)C=CC=C8F

Molecular Formula

C41H38FN5O4S

Molecular Weight

715.83

References & Citations

[1]Coates M, et al. Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor. Antimicrob Agents Chemother. 2017 Aug 24;61 (9) . pii: e00737-17.