SPP
SPP (N-succinimidyl 4- (2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].
Product Specifications
CAS Number
[341498-08-6]
Product Name Alternative
N-succinimidyl 4- (2-pyridyldithio) pentanoate
UNSPSC
12352203
Hazard Statement
H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spp.html
Purity
96.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(SSC1=NC=CC=C1)CCC(ON2C(CCC2=O)=O)=O
Molecular Formula
C14H16N2O4S2
Molecular Weight
340.43
Precautions
H315, H319, H335
References & Citations
[1]Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12 (6) :1762-73.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
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