Toxoflavin

Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4) /β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity[1][2].

Product Specifications

CAS Number

[84-82-2]

Product Name Alternative

Xanthothricin; Toxoflavine; PKF-118-310

UNSPSC

12352005

Hazard Statement

H300

Target

Antibiotic; Bacterial; Histone Demethylase; β-catenin

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/toxoflavin.html

Purity

99.88

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NC=NN(C)C1=N2)N(C)C2=O

Molecular Formula

C7H7N5O2

Molecular Weight

193.16

Precautions

H300

References & Citations

[1]Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126 (10) :2426-36.|[2]Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12 (3) :198-205.