Norfloxacin-d5
Norfloxacin-d5 is the deuterium labeled Norfloxacin. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase[1][2].
Product Specifications
CAS Number
[1015856-57-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
99.91
Solubility
10 mM in DMSO|DMSO : 5mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=CN(C([2H])([2H])C([2H])([2H])[2H])C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O
Molecular Formula
C16H13D5FN3O3
Molecular Weight
324.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et, al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216. |[2]Pohlhaus JR, et, al. Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo. Mol Microbiol. 2005 Jun;56 (6) :1416-29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Quinolone
Curated Selection
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