SPD304 (dihydrochloride)

SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2].

Product Specifications

CAS Number

[1049741-03-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/spd304-dihydrochloride.html

Purity

99.82

Solubility

DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(CN(C)CCN(C)CC2=CN(C3=CC=CC(C(F)(F)F)=C3)C4=C2C=CC=C4)=COC5=CC(C)=C(C)C=C15.[H]Cl.[H]Cl

Molecular Formula

C32H34Cl2F3N3O2

Molecular Weight

620.53

Precautions

H315, H319, H335

References & Citations

[1]Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005.|[2]Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim) . 2014 Nov;347 (11) :798-805.|[3]Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7 (1) :3424.|[4]Gallic acid induces necroptosis via TNF-α signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10 (3) :e0120713.