JNJ-DGAT2-A
JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1].
Product Specifications
CAS Number
[1962931-71-0]
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jnj-dgat2-a.html
Purity
98.26
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=C(C=CC(C#N)=C1)OC2=C(C=C(C=C2)/C=C3SC(NCCC4=CC=CC=N4)=NC\3=O)F
Molecular Formula
C24H16BrFN4O2S
Molecular Weight
523.38
References & Citations
[1]Qi J, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res. 2012 Jun;53 (6) :1106-16.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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