SF5

SF5 (2,2-Diphenylethyl isothiocyanate) is a sulforaphane analog. SF5 inhibits apoptosis by the JNK-p53-caspase pathway. SF5 can be used as a new renal protective agent for drug-resistant acute renal disease[1].

Product Specifications

CAS Number

[34634-22-5]

Product Name Alternative

2,2-Diphenylethyl isothiocyanate

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H330, H334, H335, H351, H412

Target

Apoptosis; Caspase; JNK; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sf5.html

Purity

99.83

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

S=C=NCC(C1=CC=CC=C1)C2=CC=CC=C2

Molecular Formula

C15H13NS

Molecular Weight

239.34

Precautions

H315, H317, H319, H330, H334, H335, H351, H412

References & Citations

[1]Kim T, et al. The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells. Bioorg Med Chem Lett. 2015 Jan 1;25 (1) :62-6.