FEN1-IN-3
FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1].
Product Specifications
CAS Number
[2109805-87-8]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fen1-in-3.html
Concentration
10mM
Purity
98.06
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N1O)N(C2=CC=C(OC)C=C2)C3=C(C=CC=C3)C1=O
Molecular Formula
C15H12N2O4
Molecular Weight
284.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12 (10) :815-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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