TNP (Trinitrophenol)

Fina Biosolutions’ Specialty Immunoreagents are a collection of reagents mainly of interest to immunologists. These reagents arose out of both our own research and requests from other scientists. Please let us know if there is a reagent you would like us to make. TNP-Dextran and TNP-Ficoll are classic T-cell independent model antigens. Due to the wide availability of TNP immunoreagents, they serve as useful models of natural T-cell independent antigens like polysaccharides. TNP-OVA and TNP-BSA serve as T-cell dependent model antigens with the trinitrophenyl epitope. The set of TNP reagents also allows for the selection of a suitable ELISA antigen. Our phosphorylcholine (PC) conjugates are based on the method of Chesbro and Metzger (Biochem, 11:766,1972) utilizing p-diazonium phenylphosphorylcholine. Phenylarsonate conjugates are made by the method of Amkraut et al.  (J Exp Med, 124:293,1966.) In contrast to other commercial heparin conjugates, ours utilize the terminal end of the polymer, resulting in minimum modification of the heparin.