EcoCRM (CRM197)

CGMP EcoCRM®and Research Grade EcoCRM®Available Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent antigens by linking the two together.  They are also used to improve the immunogenicity of oligosaccharides, peptides and proteins. CRM197, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines againstStreptococcus pneumoniae, Haemophilus influenzaeb andNeisseria meningitidis. Fina BioSolutions has developed a highly efficientE. coliexpression system for CRM197. We express soluble, properly folded CRM197in the cytoplasm ofE.coli. High expression levels and a simple purification scheme allow us to produce CRM197at low cost and price it accordingly. Fina Biosolutions is pleased to offerEcoCRM®, economical CRM197fromE. coli, to the research and vaccine manufacturing community.