Olmesartan medoxomil

Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.

Product Specifications

CAS Number

[144689-63-4]

Product Name Alternative

CS 866

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Olmesartan-medoxomil.html

Purity

98.95

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 12.5 mg/mL (ultrasonic)

Smiles

O=C(OCC1=C(OC(O1)=O)C)C2=C(N=C(N2CC3=CC=C(C=C3)C4=CC=CC=C4C5=NN=NN5)CCC)C(O)(C)C

Molecular Formula

C29H30N6O6

Molecular Weight

558.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38 (12) :1975-9.|[2]Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Pharm. 2012 Apr;4 (2) :88-94.|[3]Gu J, et al. Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. Kidney Blood Press Res. 2016 Nov 21;41 (6) :848-864.