Olmesartan medoxomil
Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
Product Specifications
CAS Number
144689-63-4
Product Name Alternative
CS 866
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Olmesartan-medoxomil.html
Purity
98.95
Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 12.5 mg/mL (ultrasonic)
Smiles
O=C(OCC1=C(OC(O1)=O)C)C2=C(N=C(N2CC3=CC=C(C=C3)C4=CC=CC=C4C5=NN=NN5)CCC)C(O)(C)C
Molecular Formula
C29H30N6O6
Molecular Weight
558.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38 (12) :1975-9.|[2]Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique.
 J Young Pharm. 2012 Apr;4 (2) :88-94.|[3]Gu J, et al. Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. Kidney Blood Press Res. 2016 Nov 21;41 (6) :848-864.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AT1 Receptor
Available Sizes
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