(Rac) -NSC305787 (hydrochloride)
NSC305787 hydrochloride is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity.
Product Specifications
CAS Number
53868-26-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Arp2/3 Complex
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC305787-hydrochloride.html
Purity
98.18
Solubility
DMSO : 8 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C1CCCCN1)C2=CC(C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)=NC(C(Cl)=C6)=C2C=C6Cl.[H]Cl
Molecular Formula
C25H31Cl3N2O
Molecular Weight
481.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Bulut G, et al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31 (3) :269-81.|[2]Çelik H, et al. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291 (25) :13257-70.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Cell Mol Med. 2022 Apr;26 (7) :2089-2103.|Sci Adv. 2025 Oct 24;11 (43) :eads9181.|Am J Physiol Renal Physiol. 2025 Aug 1;329 (2) :F269-F283.|Biochem Biophys Res Commun. 2024 Apr 9:703:149685.|Cell. 2023 Jan 5;186 (1) :112-130.e20.|Front Cell Dev Biol. 2021 Sep 3;9:663207.|Life Sci. 2020 Aug 1;254:117681.|PLoS Pathog. 2019 May 9;15 (5) :e1007737.
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