ML234
ML234 is a dual inhibitor against EZH2/LSD1 with IC50 values of 0.09 and 0.12 μM, respectively. ML234 displays an excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3 and 22RV1. ML234 suppresses the tumor growth in the 22RV1 xenograft mouse model. ML234 is promising for research of anticancer agents in prostate cancer[1].
Product Specifications
CAS Number
3068378-07-1
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml234.html
Smiles
CC(C(C(NCC1=C(C=C(NC1=O)C)C)=O)=CC(C2=CC=C([C@@H]3C[C@H]3N(C(OC(C)(C)C)=O)CC4CCOCC4)C=C2)=C5)=C5N(CC)C6CCOCC6
Molecular Formula
C43H58N4O6
Molecular Weight
726.94
References & Citations
[1]Le M, et al. Design, Synthesis, and Biological Evaluation of Potent EZH2/LSD1 Dual Inhibitors for Prostate Cancer. J Med Chem. 2024 Sep 12;67 (17) :15586-15605.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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