Lificiguat
Lificiguat binds to the β subunit of soluble guanylyl cyclase (sGC) with Kd of 0.6-1.1 μM in the presence of CO.
Product Specifications
CAS Number
170632-47-0
Product Name Alternative
YC-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Lificiguat.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1
Molecular Formula
C19H16N2O2
Molecular Weight
304.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Purohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53 (1) :101-14.|[2]Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7.|[3]Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171 (17) :4010-25.|[4]Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC400902 20 µg
TrkC (NTRK3) (NM_002530) Human Over-expression Lysate
Sign In for Pricing
View Details 
RDR-GOAT-Hu-01 96 Tests
Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit
Sign In for Pricing
View Details