IMR-1A
IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].
Product Specifications
CAS Number
[331862-41-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; Notch
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IMR-1A.html
Purity
98.64
Solubility
DMSO : 2 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(O)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
Molecular Formula
C13H11NO5S2
Molecular Weight
325.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76 (12) :3593-603.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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