EC144
EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases[1]. EC144 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
911397-80-3
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ec144.html
Purity
98.01
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
CC(O)(C)CC#CC1=CN(CC2=NC=C(C)C(OC)=C2C)C3=NC(N)=NC(Cl)=C31
Molecular Formula
C21H24ClN5O2
Molecular Weight
413.90
References & Citations
[1]Shi J, et al. EC144 is a potent inhibitor of the heat shock protein 90. J Med Chem. 2012;55 (17) :7786-7795.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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