4'',5''-Dehydroisopsoralidin

4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM) . 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners[1][2].

Product Specifications

CAS Number

[65639-51-2]

UNSPSC

12352005

Target

β-glucuronidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-5-dehydroisopsoralidin.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=CC3=C(C=C2C4=C1C5=C(C=C(C=C5)O)O4)C=CC(C)(C)O3

Molecular Formula

C20H14O5

Molecular Weight

334.32

References & Citations

[1]De-Wu Zhang, et al. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J Nat Med. 2012 Apr;66 (2) :362-6. |[2]Christian Limper, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65 (9) :1393-408. |[3]Tong-Hong Wang, et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat Commun. 2022 Mar 9;13 (1) :1238.