Anti-BAFF-R/BR3 (CT) Antibody

Rabbit Polyclonal Antibody specific to BAFF-R (CT) BR3

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-BAFF-R (CT) BR3 Rabbit Polyclonal Antibody

Gene Name

TNFRSF13C

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TNFRSF13C">TNFRSF13C</a>

UniProt

Q5H8V1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 169-183 at the C-terminus of human BAFF-R.

Target Antigen

BAFF receptor

Target

BAFF-R/BR3 (CT)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P, IF

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

Immunoblotting: use at 2-5 ug/mL. Positive control: human, mouse, or rat spleen tissue lysates. Immunohistochemistry: use at 5 ug/mL. Positive control: human tonsil.

Storage Conditions

This antibody is stable for one (1) year at 4°C or -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat BAFF-R.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Members of the TNF superfamily are involved in regulation of immune responses and induction of apoptosis. A novel member of the TNF superfamily, BAFF/BlyS has been characterized as a B cell activator since it stimulates B cell proliferation and immunoglobulin secretion. Two receptors for BAFF (TACI and BCMA) were first identified. A third receptor was recently identified and designated BAFF-R and BR3 for BlyS receptor 3. BAFF-R is specific for BAFF and plays a major role in BAFF-induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases and activate NF-kappaB and c-jun N-terminal kinase.