PF-06747711
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity[1].
Product Specifications
CAS Number
1892576-58-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PF-06747711.html
Purity
99.83
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=CN=C(N(C)C=C2C3CCN(C(C(C)C)=O)CC3)C2=C1C(F)(F)F)C4=CC=CC(C#N)=C4
Molecular Formula
C26H26F3N5O2
Molecular Weight
497.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Schnute ME, et al. Discovery of 3-Cyano- N- (3- (1-isobutyrylpiperidin-4-yl) -1-methyl-4- (trifluoromethyl) -1 H-pyrrolo[2,3- b]pyridin-5-yl) benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. J Med Chem. 2018 Sep 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Sall4 Mouse Monoclonal Antibody [A7A7]](https://cdn.genprice.uk/products/992/68dd1c90061270361ea82ca2/imageurl/ha601042.webp)
![PE/Cyanine7 Anti-Human CD19 Antibody[CB19]](https://cdn.genprice.uk/products/763/68dd14af061270361e7d3727/imageurl/e-ab-f1004h.webp)
E-AB-F1004H-02 100 Tests
PE/Cyanine7 Anti-Human CD19 Antibody[CB19]
Sign In for Pricing
View Details E-AB-F1004H-03 2x 100 Tests
PE/Cyanine7 Anti-Human CD19 Antibody[CB19]
Sign In for Pricing
View Details ![Retinoic Acid Receptor alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody [PSH08-74]](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea80d6f/imageurl/ha723026.webp)
HA723026 100 µL
Retinoic Acid Receptor alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody [PSH08-74]
Sign In for Pricing
View Details