PF-06747711
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity[1].
Product Specifications
CAS Number
[1892576-58-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PF-06747711.html
Purity
99.83
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=CN=C(N(C)C=C2C3CCN(C(C(C)C)=O)CC3)C2=C1C(F)(F)F)C4=CC=CC(C#N)=C4
Molecular Formula
C26H26F3N5O2
Molecular Weight
497.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Schnute ME, et al. Discovery of 3-Cyano- N- (3- (1-isobutyrylpiperidin-4-yl) -1-methyl-4- (trifluoromethyl) -1 H-pyrrolo[2,3- b]pyridin-5-yl) benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. J Med Chem. 2018 Sep 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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